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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDKL5
All Species:
0.3
Human Site:
S453
Identified Species:
0.83
UniProt:
O76039
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O76039
NP_001032420.1
1030
115538
S453
S
F
M
E
S
S
Q
S
K
A
G
T
L
Q
P
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
NP_001129485
570
64691
V18
G
E
G
S
Y
G
M
V
V
K
C
R
N
K
D
Dog
Lupus familis
XP_548881
960
107395
H404
L
T
N
N
N
I
P
H
L
L
S
P
K
E
A
Cat
Felis silvestris
Mouse
Mus musculus
Q3UTQ8
938
105471
A386
M
H
T
K
T
Y
Q
A
S
T
Q
P
G
S
S
Rat
Rattus norvegicus
Q5XIT0
507
57117
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514328
967
107039
N404
A
K
D
L
A
N
N
N
I
P
H
L
L
S
P
Chicken
Gallus gallus
XP_425571
960
107495
L405
A
N
N
N
M
P
H
L
L
S
P
K
E
T
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001124243
1039
116666
S477
R
H
N
Y
M
E
S
S
H
G
S
M
P
S
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796071
627
72401
K75
E
A
F
R
R
R
G
K
L
Y
L
V
F
E
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
26.7
88.1
N.A.
85.9
23.6
N.A.
76.5
75.2
N.A.
55.3
N.A.
N.A.
N.A.
N.A.
25.5
Protein Similarity:
100
N.A.
39.5
89.7
N.A.
88.9
36.5
N.A.
82.5
83.6
N.A.
69.1
N.A.
N.A.
N.A.
N.A.
39
P-Site Identity:
100
N.A.
0
0
N.A.
6.6
0
N.A.
13.3
0
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
N.A.
6.6
13.3
N.A.
26.6
0
N.A.
40
13.3
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
23
12
0
0
12
0
0
12
0
12
0
0
0
0
12
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
12
0
0
0
0
% C
% Asp:
0
0
12
0
0
0
0
0
0
0
0
0
0
0
12
% D
% Glu:
12
12
0
12
0
12
0
0
0
0
0
0
12
23
0
% E
% Phe:
0
12
12
0
0
0
0
0
0
0
0
0
12
0
0
% F
% Gly:
12
0
12
0
0
12
12
0
0
12
12
0
12
0
0
% G
% His:
0
23
0
0
0
0
12
12
12
0
12
0
0
0
0
% H
% Ile:
0
0
0
0
0
12
0
0
12
0
0
0
0
0
0
% I
% Lys:
0
12
0
12
0
0
0
12
12
12
0
12
12
12
12
% K
% Leu:
12
0
0
12
0
0
0
12
34
12
12
12
23
0
0
% L
% Met:
12
0
12
0
23
0
12
0
0
0
0
12
0
0
0
% M
% Asn:
0
12
34
23
12
12
12
12
0
0
0
0
12
0
0
% N
% Pro:
0
0
0
0
0
12
12
0
0
12
12
23
12
0
23
% P
% Gln:
0
0
0
0
0
0
23
0
0
0
12
0
0
12
0
% Q
% Arg:
12
0
0
12
12
12
0
0
0
0
0
12
0
0
0
% R
% Ser:
12
0
0
12
12
12
12
23
12
12
23
0
0
34
12
% S
% Thr:
0
12
12
0
12
0
0
0
0
12
0
12
0
12
12
% T
% Val:
0
0
0
0
0
0
0
12
12
0
0
12
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
12
12
12
0
0
0
12
0
0
0
0
12
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _